Radiometal-theranostics: the first 20 years*

نویسندگان

چکیده

Abstract This review describes the basic principles of radiometal-theranostics and its dawn based on development positron-emitting 86 Y Y-labeled radiopharmaceuticals to quantify biodistribution dosimetry 90 analogue therapeutics. The nuclear inorganic (including cross section data, irradiation, radiochemical separation recovery) led preclinical clinical evaluation citrate EDTMP complexes yielded organ radiation doses in terms mGy/MBq Y. approach was extended [ 86/90 Y]Y-DOTA-TOC, yielding again further discusses consequences this early radiometals that were used ( 68 Ga, 177 Lu etc.), more chelators developed, new biological targets addressed (SSTR, PSMA, FAP, etc.) subsequent generations resulted out that.

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ژورنال

عنوان ژورنال: Journal of Radioanalytical and Nuclear Chemistry

سال: 2022

ISSN: ['0236-5731', '1588-2780']

DOI: https://doi.org/10.1007/s10967-022-08624-3